Joshua R. Bush, Ph.D.

Joshua R. Bush, Ph.D.

Biotech Executive | R&D Leader | Biomedical Engineer
1779 Kirby Pkwy #1 PMB #136, 38138-0631, Memphis, US.

About

Highly accomplished Ph.D. in Chemical Engineering with over two decades of expertise in biomedical engineering, biomaterials, and regenerative medicine. Proven leader in biotech commercialization, R&D strategy, and scientific innovation, adept at translating cutting-edge research into market-ready solutions and securing significant grant funding. Drives product development, fosters strategic partnerships, and excels in leading diverse research teams to achieve impactful scientific and business outcomes.

Work

NatureFound Biotech, Inc.
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CEO/President

Memphis, TN, US

Summary

Led a biotech startup focused on commercializing patented solutions from the University of Memphis, driving product development and strategic partnerships.

Highlights

Spearheaded the commercialization strategy for biotech solutions patented at the University of Memphis, translating cutting-edge research into viable products.

Directed the development and application of advanced dental membranes for Guided Bone Regeneration (GBR) and Guided Tissue Regeneration (GTR) applications.

Cultivated strategic collaborations with Epicenter Memphis and the University of Memphis as a Deep Science R&D Entrepreneurship Fellow to accelerate market entry and foster regional economic growth.

University of Memphis
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Postdoctoral Fellow, Department of Biomedical Engineering

Memphis, TN, US

Summary

Conducted advanced research in biomedical engineering, focusing on biomaterial development, immune response, and therapeutic delivery for critical medical applications.

Highlights

Engineered electrospun natural-polymer materials for enhanced burn-wound healing and targeted drug delivery, demonstrating efficacy in in vivo models.

Investigated immune cell responses to natural polymers and fatty acids, generating critical insights into biocompatibility and therapeutic mechanisms.

Developed innovative microgel particles for the precise delivery of natural bactericides, significantly improving treatment strategies for traumatic injuries.

Mentored and supervised multiple graduate and undergraduate students, fostering scientific development and research capabilities.

Served as Co-Guest Editor for two significant special issues: “Biomaterials in Regenerative Medicine” (Frontiers in Bioscience, 2023) and “Application of Marine Chitin and Chitosan II” (Marine Drugs, 2022).

Natural Scaffolds, Inc.
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Founder/Research Scientist

Charlottesville, VA, US

Summary

Founded and led research for a biomaterials company, developing natural-polymer hydrogels for orthopedic applications and exploring their immunomodulatory effects.

Highlights

Pioneered the development of a natural-polymer hydrogel specifically designed for advanced orthopedic applications.

Identified and characterized the crucial link between hydrogel formulations and beneficial immune system changes, enhancing therapeutic potential.

Managed all scientific research and development activities as founder, driving innovation from concept to early-stage product development over a 9-year tenure.

University of Virginia
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Research Scientist, Department of Orthopaedic Surgery

Charlottesville, VA, US

Summary

Led independent research as Principal Investigator, securing significant grant funding to develop natural polymer hydrogels for regenerative medicine and bone injury healing.

Highlights

Secured and managed independent funding as Principal Investigator for two distinct grant awards, totaling $185,000 (DOD Hypothesis Development Award: $150,000; R. Clifton Brooks, Jr. Medical Research Fund: $35,000).

Developed novel hydrogels from natural polymers, demonstrating effectiveness in healing bone injuries through both in vitro and in vivo models for regenerative medicine.

Conducted advanced studies on synergistic protein delivery to traumatic bone fractures, directly contributing to a biomaterial patent application.

University of Virginia
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Research Fellow, Department of Orthopaedic Surgery

Charlottesville, VA, US

Summary

Conducted advanced biomaterials research, focusing on hydrogel development, surface modification, and fostering scientific collaboration within the orthopaedic surgery department.

Highlights

Developed a novel thermally-responsive hydrogel system for the controlled delivery of therapeutic proteins, enhancing treatment precision.

Utilized laser-textured titanium to optimize osteoblast and stem cell adhesion, significantly improving implant integration and bone regeneration.

Organized and successfully led three interdepartmental research symposiums, fostering collaboration and knowledge exchange across diverse scientific disciplines.

Awarded the prestigious Institutional NRSA Research Fellowship, recognizing excellence in biomedical research and promising scientific contributions.

Education

Texas A&M University
College Station, TX, United States of America

Ph.D.

Chemical Engineering

North Carolina State University
Raleigh, NC, United States of America

M.S.

Chemical Engineering

North Carolina State University
Raleigh, NC, United States of America

B.S.

Chemical Engineering

Awards

DOD Hypothesis Development Award

Awarded By

Department of Defense

Awarded $150,000 to investigate synergistic protein delivery from injectable hydrogels for advanced therapeutic applications.

R. Clifton Brooks, Jr. Medical Research Fund

Awarded By

R. Clifton Brooks, Jr. Medical Research Fund

Received $35,000 in funding to synthesize novel hydrogels from natural polymers, enhancing material biocompatibility and cellular healing responses.

Institutional NRSA Research Fellowship Award

Awarded By

University of Virginia

Recognized for promising biomedical research contributions and excellence in the field of orthopaedic surgery.

Staff Member of the Year

Awarded By

AIChE Student Chapter

Recognized for outstanding contributions and dedication to the American Institute of Chemical Engineers Student Chapter.

Publications

Chitosan membranes stabilized with varying acyl lengths release cis-2-decenoic acid and bupivacaine at controlled rates and inhibit pathogenic biofilm.

Published by

Frontiers in Bioscience-Landmark

Cis-2-decenoic acid and bupivacaine delivered from electrospun chitosan membranes increase cytokine production in dermal and inflammatory cell lines.

Published by

Pharmaceutics

Titanium coated with 2-decenoic analogs reduces bacterial and fungal films.

Published by

Journal of Applied Microbiology

Xylan hemicellulose improves chitosan hydrogel for bone tissue regeneration.

Published by

Polymers for Advanced Technologies

Methods for Regulating Gelation of Hydrogel Solutions and Uses Thereof.

Published by

US Patent Application Publication No. US8623403B2

Improved Bio-implant using Ultrafast Laser Induced Self-assembled Nanotexture in Titanium.

Published by

Journal of Biomedical Materials Research Part B: Applied Biomaterials

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects.

Published by

Journal of Visualized Experiments

Synthesis of Controlled Release Device with Supercritical CO2 and Co-solvent.

Published by

Journal of Supercritical Fluids

Skills

Biomaterials & Regenerative Medicine

Hydrogel Development, Electrospun Polymers, Microgel Particles, Chitosan, Hemicellulose, Titanium Surface Modification, Protein Delivery, Bone Tissue Engineering, Wound Healing, Drug Delivery Systems, Orthopedic Applications, GBR/GTR Applications.

Research & Development

In Vitro Models, In Vivo Models, Immune Cell Response, Biofilm Inhibition, Grant Writing, Patent Development, Scientific Writing, Experimental Design, Data Analysis, Literature Review, Biostatistics.

Biotech Commercialization & Entrepreneurship

Startup Leadership, Product Development, Market Entry Strategy, Strategic Partnerships, Technology Transfer, R&D Management, Deep Science Entrepreneurship.

Leadership & Mentorship

Team Leadership, Project Management, Graduate Student Mentoring, Undergraduate Student Mentoring, Scientific Symposium Organization, Cross-functional Collaboration, Editorial Leadership.

Chemical Engineering

Mass Transfer Operations, Chemical Engineering Principles, Process Optimization.